Arrhythmias & electrophysiology
Five-Year Risk of Stroke after Transient Ischemic Attack (TIA) or Minor Ischemic Stroke
Authors' conclusion
In a follow-up to a 1-year study involving patients who had a TIA or minor stroke, the rate of cardiovascular events including stroke in a selected cohort was 6.4% in the first year and 6.4% in the second through fifth years.
Study context
- Population
- Patients with TIA or minor ischemic stroke within 7 days before enrollment, TIA clinics in 21 countries, 2009–201142 of 61 sites
- Participants
- 3,847 patients
- Outcome
- Composite of:
- Stroke
- ACS or CV death (whichever first)
- Emphasis on events in years 2–5
- Follow-up
- 5 years
Methodological details5-year follow-up of the TIA clinic registry, international registry, 21 countries, 42 sites, death treated as competing risk, Median per-centre 5-year follow-up 92.3% (IQR 83.4 to 97.8)
- 5-year follow-up of the TIA clinic registry
- International registry
- 21 countries
- 42 sites
- Death treated as competing risk
- Median per-centre 5-year follow-up 92.3% (IQR 83.4 to 97.8)
Main finding
As reported in the abstract
Composite of:
- Stroke
- ACS
- CV death
Patients with primary outcome event
469
Estimated cumulative rate
12.9%
95% CI 11.8 to 14.1
Events in years 2–5
235
50.1%
Observational data: associations, not effects.
Secondary outcomes
Stroke · 5 years
- Patients with stroke
- 345
- Estimated cumulative rate
- 9.5% (95% CI 8.5 to 10.5)
- Stroke in years 2–5
- 149 (43.2%)
All-cause death and CV death · 5 years
- All-cause death
- 10.6%
- CV death
- 2.7%
Predictors of subsequent stroke (multivariable)
- Ipsilateral large-artery atherosclerosis, cardioembolism and baseline ABCD2 score ≥4 each associated with increased risk of subsequent stroke
Safety
Intracranial hemorrhage and major bleeding · 5 years
- Intracranial hemorrhage
- 1.1%
- Major bleeding
- 1.5%
Original publication
Five-Year Risk of Stroke after TIA or Minor Ischemic Stroke. N Engl J Med. Published 16 May 2018. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →