Fractional Flow Reserve–Guided Renal Artery Stenting in Renovascular Hypertension: 1-Year Results of the FAIR Study
Authors' conclusion
At the 1-year follow-up, FFR-guided renal artery stenting reduced stent use without loss of blood pressure control or renal safety compared with angiography guidance.
Study context
- Population
- Adults with atherosclerotic renal artery stenosis (ARAS)1-year follow-up: 50 fractional flow reserve (FFR)-guided, 51 angiography-guided
- Participants
- 107 adults
- Comparison
- FFR-guided vs angiography-guided renal artery stenting
- Primary endpoint
- % change in ambulatory daytime mean SBP (DMSBP), composite index of antihypertensive medicines (CIAHM) and renal outcomes
- Follow-up
- 1 year
Methodological detailsinvestigator-initiated, multicentre, open-label, blinded endpoint adjudication, 1:1
- Investigator-initiated
- Multicentre
- Open-label
- Blinded endpoint adjudication
- 1:1
Primary result
As reported in the abstract
DMSBP, CIAHM and renal outcomes
- Daytime mean systolic blood pressure (DMSBP), composite index of antihypertensive medicines (CIAHM) and renal outcomes similar between the groups
Further findings
Stenting rate · 1 year
P < 0.01
ΔDMSBP in patients with FFR <0.80 who underwent stenting (subgroup)
- 3 months, median [IQR]
- 13 [4, 21] mm Hg
- 6 months, median [IQR]
- 8 [3, 16] mm Hg
- 12 months, median [IQR]
- 7 [0, 16] mm Hg
- All paired P < 0.05
CIAHM decline in patients with FFR <0.80 who underwent stenting (subgroup) · 3, 6 and 12 months
- Median [IQR] decline
- 2 [0, 5]
- All paired P < 0.05
12-month eGFR after stenting
- Significant eGFR improvement only when FFR <0.80
- Quantile regression analysis
Original publication
Fractional Flow Reserve–Guided Renal Artery Stenting in Renovascular Hypertension: 1-Year Results of the FAIR Study. JACC Cardiovasc Interv. Published 13 July 2026. doi:10.
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