Fractional flow reserve- and intravascular ultrasound-guided strategies for intermediate coronary stenosis and low lesion complexity in patients with or without diabetes: a post hoc analysis of the randomised FLAVOUR trial
Authors' conclusion
In patients with intermediate coronary stenosis and low lesion complexity, regardless of diabetic status, FFR guidance had no significant differences in MACE or TVF with a lower frequency of PCI compared with IVUS guidance.
Study context
- Population
- Patients with intermediate coronary artery stenosis and low lesion complexity, with or without diabetesrandomly assigned patients, 554 (32.9%) had diabetes
- Participants
- 1,682 patients
- Comparison
- Fractional flow reserve (FFR) vs intravascular ultrasound (IVUS)
- Primary endpoint
- Major adverse cardiac events (MACE):
- Death
- Myocardial infarction
- Any revascularisation
- Follow-up
- 24 months
Methodological detailsrandomised
- Randomised
Primary result
As reported in the abstract
Cumulative incidence
9.3% vs 8.3%
P = 0.90
diabetic patients
Cumulative incidence
7.5% vs 8.6%
P = 0.50
non-diabetic patients
Secondary outcomes
| Outcome | PCI rate | P value |
|---|---|---|
| PCI rateFFR vs IVUS · diabetic patients; lower with FFR | 48.2% vs 69.1% | P < 0.001 |
| PCI rateFFR vs IVUS · non-diabetic patients; lower with FFR | 42.6% vs 63.3% | P < 0.001 |
Baseline SYNTAX score
- Mean SYNTAX score
- 8.64±6.03
Target vessel failure (TVF) · 24 months
- Cumulative incidence of TVF comparable between FFR and IVUS groups regardless of diabetic status
Original publication
Fractional flow reserve- and intravascular ultrasound-guided strategies for intermediate coronary stenosis and low lesion complexity in patients with or without diabetes: a post hoc analysis of the randomised FLAVOUR trial. EuroIntervention. Published 3 February 2025. doi:10.
Summarised from the published abstract; every number is checked against it