Frailty and cardiovascular outcomes in the National Health and Aging Trends Study
Authors' conclusion
In patients without CHD, frailty is a risk factor for the development of MACEs.
Study context
- Population
- Older adults without history of coronary heart disease (CHD), National Health and Aging Trends Studywithout CHD, of 4656
- Participants
- 3,259 adults
- Exposure
- Frail vs non-frail
- Outcome
- All-cause mortality and major adverse cardiovascular event (MACE)
- Follow-up
- 6-year follow-up
Methodological detailslinked to a Medicare sample
- Linked to a Medicare sample
Main finding
As reported in the abstract
Frail vs Non-frailHazard ratio (95% CI)
MACE
1.77(1.53–2.06)
Death
2.70(2.16–3.38)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| Individual CV outcomes · 6-year follow-upFrail vs Non-frail · acute MI · Cox multivariable model | 1.95 (1.31–2.90) | |
| Individual CV outcomes · 6-year follow-upFrail vs Non-frail · stroke · Cox multivariable model | 1.71 (1.34–2.17) | |
| Individual CV outcomes · 6-year follow-upFrail vs Non-frail · peripheral vascular disease · Cox multivariable model | 1.80 (1.44–2.27) | |
| Individual CV outcomes · 6-year follow-upFrail vs Non-frail · CAD · Cox multivariable model | 1.35 (1.11–1.65) | |
| 0.20.5125Hazard ratio (log scale) |
Original publication
Frailty and cardiovascular outcomes in the National Health and Aging Trends Study. Eur Heart J. Published 29 July 2021. doi:10.
Summarised from the published abstract; every number is checked against it