Frailty and Cognitive Function in Middle-Aged and Older Adults With Congenital Heart Disease
Authors' conclusion
Approximately one-half of included patients were (pre-)frail, and more than one-third experienced cognitive impairment. Frailty and cognitive dysfunction were identified in patients with mild CHD, indicating that these concerns extend beyond severe CHD.
Study context
- Population
- Adults aged ≥40 years with congenital heart disease (CHD)
- Participants
- 814 adults11 countries
- Outcome
- Frailty phenotype (Fried method) and cognitive function (Montreal Cognitive Assessment)
Methodological detailsmulticentre, 11 countries
- Multicentre
- 11 countries
Main finding
As reported in the abstract
Robust
52.3%
Prefrail
41.9%
Frail
5.8%
Cognitive dysfunction
38.8%
Observational data: associations, not effects.
Further findings
Predictors of frailty (multinomial regression)
- Frailty associated with older age, female sex, higher physiologic class and comorbidities
- Mild heart defects more likely than complex lesions to be prefrail
- More prefrailty in middle-income than higher-income countries
Predictors of cognitive dysfunction (logistic regression)
- Cognitive dysfunction related to older age, comorbidities and lower country-level income
Original publication
Frailty and Cognitive Function in Middle-Aged and Older Adults With Congenital Heart Disease. J Am Coll Cardiol. Published 26 March 2024. doi:10.
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