Fetal Hemodynamics, Early Survival, and Neurodevelopment in Patients With Cyanotic Congenital Heart Disease
Authors' conclusion
Among fetuses with cyanotic CHD, diminished fetal combined ventricular output is associated with mortality, whereas cerebral blood flow and oxygen delivery are associated with early cognitive, language, and motor development at 18 months of age.
Study context
- Population
- Fetuses with cyanotic congenital heart disease undergoing late gestational fetal cardiovascular magnetic resonance (CMR)71 with neurodevelopmental (ND) outcomes assessed
- Participants
- 144 fetuses
- Outcome
- Mortality and Bayley Scales of Infant Development-III assessment
- Follow-up
- 18 months
Main finding
As reported in the abstract
- Mortality by 18 months
- 18 (12.5%)
- Mortality associated with reduced combined ventricular output
- P = 0.01
- Mortality associated with reduced descending aortic flow
- P = 0.04
- Mortality associated with reduced umbilical vein flow
- P = 0.03
- Cerebral oxygen delivery most strongly associated with cognitive, language and motor outcomes
- P < 0.05
- Fetal superior vena cava (SVC) flow associated with cognitive, language and motor outcomes
- P < 0.01
- SVC flow independent predictor of cognitive outcome after adjusting for diagnosis
- P = 0.002
- SVC flow independent predictor of language outcome after adjusting for diagnosis
- P = 0.04
- Diminished SVC flow predicting cognitive ND delay, ROC AUC (better than other fetal CMR and echocardiographic predictors)
- 0.85; SE 0.05
Observational data: associations, not effects.
Original publication
Fetal Hemodynamics, Early Survival, and Neurodevelopment in Patients With Cyanotic Congenital Heart Disease. J Am Coll Cardiol. Published 25 March 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →