Heart failure & cardiomyopathies
Frailty in Heart Failure According to the Presence or Absence of Wild-Type Transthyretin Cardiac Amyloidosis
Authors' conclusion
ATTRwt CA is associated with a specific frailty phenotype.
Study context
- Population
- Consecutive heart failure (HF) patients, April 2018 to April 2021; mean age 80.9 years, 87% male
- Participants
- 123 patients
- Exposure
- HF with ATTRwt CA vs HF without ATTRwt CA
- HF + ATTRwt+n = 68
- HF + ATTRwt-n = 55reference
- Outcome
- Frailty parameters assessed using multidimensional geriatric tools
Methodological detailscomparative, prospective, consecutive patients
- Comparative
- Prospective
- Consecutive patients
Main finding
As reported in the abstract
Frailty parameters
HF + ATTRwt+ vs HF + ATTRwt-Odds ratio (95% CI)P value
Balance disorders
1.8(1.1–2.8)
P = 0.02Memory complaints
2.5(1.0–5.9)
P = 0.05Overactive bladder
1.5(1.1–2.2)
P = 0.03Very frail (not significant)
2.4(0.9–6.9)
P = 0.10- Shrinking
- OR 2.9 (95% CI 1.1–1.7); P = 0.03
Observational data: associations, not effects.
Original publication
Frailty in Heart Failure According to the Presence or Absence of Wild-Type Transthyretin Cardiac Amyloidosis. ESC Heart Fail. Published 16 September 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →