Heart failure & cardiomyopathies
MRI-Extracellular Volume Fraction Versus Histological Amyloid Load in Cardiac Amyloidosis: The Importance of T2 Mapping
Authors' conclusion
In patients with ATTRwt-CM and prolonged T2, MRI-ECV did not accurately reflect histological amyloid load. Our findings underscore the need for a multiparametric imaging approach, combining both ECV and T2 mapping, to better characterize myocardial tissue in patients with ATTRwt-CM, and further prospective research in larger and more diverse cohorts is needed to validate our results.
Study context
- Population
- Patients with wild-type transthyretin amyloid cardiomyopathy (ATTRwt-CM) who underwent endomyocardial biopsy and cardiac magnetic resonance imaging (MRI) for initial evaluation, March 2017 to October 202124 showed T2 prolongation (T2≥50 milliseconds)
- Participants
- 44 patients
- Exposure
- Correlation between MRI-ECV and amyloid load from endomyocardial biopsy, with and without T2 prolongation
- T2 prolongationn = 24
- Outcome
- Correlation between MRI-ECV and amyloid load, absence of T2 prolongation
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
As reported in the abstract
Spearman ρ
ρ=0.50, P =0.03
Observational data: associations, not effects.
Further findings
Correlation between MRI-ECV and amyloid load, presence of T2 prolongation
- Spearman ρ
- ρ=−0.05, P =0.83
Interval between endomyocardial biopsy and cardiac MRI
- Median
- 3 days (interquartile range, 2-4)
- All specimens obtained by endomyocardial biopsy were suitable for analysis
Original publication
MRI-Extracellular Volume Fraction Versus Histological Amyloid Load in Cardiac Amyloidosis: The Importance of T2 Mapping. Circ Cardiovasc Imaging. Published 21 March 2025. doi:10.
Summarised from the published abstract; every number is checked against it