Addition of Computed Tomography–Derived Fractional Flow Reserve in the Diagnostic Pathway of Patients With Stable Coronary Artery Disease: The FUSION Randomized Controlled Trial
Primary result · ICA without obstructive CADResult — go to the resultOdds ratio 0.46 95% CI 0.31–0.69Authors' conclusion
Adding FFRct to the diagnostic pathway of patients with a 50% to 90% stenosis on CCTA reduced the rate of ICA without obstructive CAD at 90 days and 1 year, without differences in revascularizations, quality of life, and costs compared with usual care.
Study context
- Population
- Stable coronary artery disease (CAD) patients with 50% to 90% stenosis in ≥1 coronary artery on coronary computed tomography angiography (CCTA)
- Participants
- 528 patients
- Comparison
- FFRct-guided vs usual care
- FFRctn = 263
- Usual caren = 265reference
- Primary endpoint
- ICA without obstructive CAD
- Follow-up
- 90 days
Methodological detailsinvestigator-initiated, multicentre
- Investigator-initiated
- Multicentre
Primary result
ICA without obstructive CAD
Odds ratio
0.46
95% CI 0.31–0.69
P < 0.001
Events by treatment group
As reported in the abstract
Secondary outcomes
ICA use (post hoc exploratory) · 90 days · post hoc exploratory endpoint
P = 0.004
| Outcome | P value |
|---|---|
| Revascularization · 1 year | P = 0.948 |
Invasive coronary angiography (ICA) without obstructive CAD and ICA use · 1 year
- Both differences persisted at 1 year
Quality of life, costs, MACE
- Did not differ between groups; clinical event rates low
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Summarised from the published abstract; every number is checked against it