Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy
Authors' conclusion
The findings indicate that genes related to blood pressure traits are associated with preeclampsia, but many of these genes have additional pleiotropic effects on cardiometabolic, endothelial, and placental function.
Study context
- Population
- Women with preeclampsia or other hypertensive disorders of pregnancy and controls, Finnish and Estonian cohorts and InterPregGen consortium
- Participants
- 16,743 vs 15,200
- Comparison
- Preeclampsia vs Preeclampsia or other maternal hypertension
- Preeclampsian = 16,743
- Preeclampsia or other maternal hypertensionn = 15,200
- Outcome
- Genome-wide association of genetic variants with preeclampsia and with preeclampsia or other maternal hypertension during pregnancy
Methodological detailsmeta-analysis, meta-analysis of 4 cohorts/consortia (FINNPEC, FinnGen, Estonian Biobank, InterPregGen), Data analysed July 2020 to February 2023
- Meta-analysis
- Meta-analysis of 4 cohorts/consortia (FINNPEC, FinnGen, Estonian Biobank, InterPregGen)
- Data analysed July 2020 to February 2023
Pooled result
As reported in the abstract
Genome-wide significant associations
Genome-wide significant associations
19
Novel loci
13
Novel loci harbouring genes previously associated with BP traits (NPPA, NPR3, PLCE1, TNS2, FURIN, RGL3, PREX1)
7
Original publication
Genetic Risk Factors Associated With Preeclampsia and Hypertensive Disorders of Pregnancy. JAMA Cardiol. Published 1 July 2023. doi:10.
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