Heart failure & cardiomyopathies
Genetically predicted iron status and cardiovascular function and structure: a Mendelian randomization study
Authors' conclusion
Our study provides MR evidence that iron status may alter cardiovascular function and structure.
Study context
- Population
- UK Biobank participants with cardiac imaging (left ventricular end-diastolic volume (LVEDV), left ventricular end-systolic volume (LVESV), left ventricular ejection fraction (LVEF), left ventricular mass (LVM), LVMVR); iron variants from 257,953 subjects across six cohortsiron GWAS: 257,953 subjects, 6 cohorts
- Comparison
- Genetically predicted iron biomarkers and LV function and structure
Methodological detailstwo-sample Mendelian randomization (MR)
- Two-sample MR
Main finding
As reported in the abstract
- Serum iron (per 1 SD increase) · LVEDV (lower)
- beta −0.11 (95% CI −0.19 to −0.03); P = 0.006
- Serum iron (per 1 SD increase) · LVESV (lower)
- beta −0.11 (95% CI −0.19 to −0.03); P = 0.007
- Transferrin saturation (TSAT) (per 1 SD increase) · LVMVR (higher)
- beta 0.09 (95% CI 0.03–0.15); P = 0.005
Further findings
Sensitivity analyses (heterogeneity, pleiotropy, bidirectional MR)
- Heterogeneity, pleiotropy and bidirectional effects not observed
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Genetically predicted iron status and cardiovascular function and structure: a Mendelian randomization study. Eur J Prev Cardiol. Published 5 August 2025. doi:10.
Summarised from the published abstract; every number is checked against it