Arrhythmias & electrophysiology
Genome-wide association study-identified novel genetic loci for QT interval in Taiwan: implications for population-specific arrhythmia risk
Authors' conclusion
This is the first GWAS of QT interval in a Taiwanese cohort, revealing novel loci at GJA1 and CD46/MIR29B2CHG.
Study context
- Population
- Taiwanese population (Taiwan Biobank participants); replication in NTU-AF Registryreplication cohort 2011
- Participants
- 13,020 participants
- Outcome
- Genetic determinants (genome-wide significant loci, P < 5 × 10-8) of QTc interval
Methodological detailsmulti-stage, independent replication cohort, Axiom Taiwan-specific Taiwan Biobank (TWB) array; ∼4.5 million imputed SNPs tested
- Multi-stage
- Independent replication cohort
- Axiom Taiwan-specific TWB array; ∼4.5 million imputed SNPs tested
Main finding
As reported in the abstract
Loci associated with QTc interval
Significant loci identified, including known QT loci/genes (KCNQ1, KCNH2, KCNE1, NOS1AP)
11
Novel loci identified and replicated: rs55797717 (CD46/MIR29B2CHG) at 1q32.2 and rs76715387 (GJA1) at 6q22.31
2
Observational data: associations, not effects.
Further findings
Colocalization with gene expression
- rs55797717 linked to CD46 expression in atrial appendage and MIR29B2CHG in LV; rs76715387 to GJA1 expression in tibial artery
Original publication
Genome-wide association study-identified novel genetic loci for QT interval in Taiwan: implications for population-specific arrhythmia risk. Europace. Published 7 April 2026. doi:10.
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