Genome-wide association study identifies 18 novel loci associated with left atrial volume and function
Authors' conclusion
We report on 18 genetic loci associated with LA volume and function and show evidence for several plausible candidate genes important for LA structure.
Study context
- Population
- European UK Biobank participants with CMR imaging
- Participants
- 35,658 participants
- Outcome
- Genetic loci associated with 5 volumetric and functional LA variables
Methodological detailsUK Biobank, machine learning-derived CMR phenotypes
- UK Biobank
- Machine learning-derived CMR phenotypes
Main finding
As reported in the abstract
Genetic loci associated with LA volume and function
Novel genetic loci identified, mapped to genes with roles in cardiomyopathy (e.g. MYO18B, TTN, DSP, ANKRD1) and arrhythmia (e.g. TTN, CASQ2, MYO18B, C9orf3)
18
Further findings
| Outcome | Estimate | P value |
|---|---|---|
| AF polygenetic risk score and LA traits in participants without AFAF polygenetic risk (per SD) | LAmax 0.25 (mL/m²)/SD (95% CI 0.15–0.36) | P = 5.13 × 10-6 |
| AF polygenetic risk score and LA traits in participants without AFAF polygenetic risk (per SD) | LAmin 0.21 (mL/m²)/SD (95% CI 0.15–0.28) | P = 1.86 × 10-10 |
| AF polygenetic risk score and LA traits in participants without AFAF polygenetic risk (per SD) | LA active emptying fraction −0.35 %/SD (95% CI −0.43 to −0.26) | P = 3.14 × 10-14 |
Genetic correlation of left atrial (LA) passive emptying fraction with stroke
- Rg
- 0.40
- P
- P = 4 × 10-6
- Most pronounced of the LA traits
Original publication
Genome-wide association study identifies 18 novel loci associated with left atrial volume and function. Eur Heart J. Published 2 August 2021. doi:10.
Summarised from the published abstract; every number is checked against it