Heart failure & cardiomyopathies
Geographical Variation in Patient Characteristics and Outcomes in Heart Failure with Mildly Reduced and Preserved Ejection Fraction
Authors' conclusion
There is substantial geographic variation in patient characteristics, treatment and outcomes among patients with HFpEF and HFmrEF.
Study context
- Population
- Patients with HF with preserved ejection fraction (HFpEF) or HF with mildly reduced ejection fraction (HFmrEF) enrolled in five clinical trials
- Participants
- 19,959 patients5 trials
- Comparison
- Geographic regions
- Outcome
- CV death or HF hospitalization
Methodological detailspooled individual patient data, multivariable regression
- Pooled individual patient data
- Multivariable regression
Pooled result
As reported in the abstract
CV death or HF hospitalization, HFmrEF (per 100 patient-years)
Further pooled results
| Outcome | Values |
|---|---|
| CV death or HF hospitalization, HFpEF (per 100 patient-years) | NA 11.47 /100py · AP 7.80 /100py · CEER 5.47 /100py · LA 5.92 /100py · WE 7.80 /100py |
- CV death or heart failure (HF) hospitalization, HFpEF (per 100 patient-years): HFpEF n = 15 353 (76.9%)
Patient characteristics by region
- Western Europe (WE) oldest, Central/Eastern Europe and Russia (CEER) youngest; Latin America (LA) most females; North America (NA) most black patients
- Obesity and DM most prevalent in NA; hypertension and CHD most common in CEER
- Self-reported health status worst in NA, best in Asia-Pacific (AP)
Original publication
Geographical Variation in Patient Characteristics and Outcomes in Heart Failure with Mildly Reduced and Preserved Ejection Fraction. Eur J Heart Fail. Published 23 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →