Geographic Differences in Patients with Acute Myocardial Infarction in the PARADISE-MI Trial
Authors' conclusion
In PARADISE-MI, there were substantial regional differences in patient characteristics, treatments and outcomes.
Study context
- Population
- Patients with acute MI in the PARADISE-MI trial
- Comparison
- Regions of enrolment
- Primary endpoint
- CV death or incident HF
Primary result
As reported in the abstract
Primary composite outcome:
- CV death
- Incident HF
South Asia (SA)
4.6/100 person-years
Latin America (LA)
9.2/100 person-years
Further findings
| Outcome | Values |
|---|---|
| Incident HF, by region | SA 1.0/100 person-years · Northern Europe 5.9/100 person-years |
| Medication use, by region | SA ACEi/ARB 34.8% · Beta-blockers 65.5% · NA MRA (lowest) 22% · Eastern Europe/Russia MRA (highest) 53% |
Incident HF, by region
- Rates varied almost six-fold among regions
Patient characteristics, by region
- Asian, particularly SA, patients younger and thinner, more DM, less AF, more often STEMI, low rate of primary PCI
- LA patients did not differ meaningfully from Europe or North America (NA)
Original publication
Geographic Differences in Patients with Acute Myocardial Infarction in the PARADISE-MI Trial. Eur J Heart Fail. Published 28 April 2023. doi:10.
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