Acute cardiac care & resuscitation
Glycemic patterns and impact of early hyperglycaemia in patients with cardiogenic shock on mechanical circulatory support
Main finding · 30-day all-cause mortalityResult — go to the resultAdjusted odds ratio 2.27 95% CI 1.19–4.42Authors' conclusion
The presence of early hyperglycaemia in these patients acted predominantly as a surrogate of the underlying shock severity and was associated with worse short-term outcomes.
Study context
- Population
- Adults with cardiogenic shock on temporary mechanical circulatory support (MCS) (intra-aortic balloon pump (IABP), Impella or VA-ECMO), Cleveland Clinic cardiac intensive care unit (CICU), 2015–2019
- Participants
- 393 adults
- Exposure
- Early mean blood glucose (MBG) >180 vs 140–180 vs <140 mg/dL after MCS insertion
- Group 1n = 174
- Group 2n = 126
- Group 3n = 93
- Outcome
- All-cause mortality
- Follow-up
- 30 days
Methodological detailssingle-centre, Blood glucose collected for first 72 h from MCS insertion
- Single-centre
- Blood glucose collected for first 72 h from MCS insertion
Main finding
30-day all-cause mortality
Adjusted odds ratio
2.27
95% CI 1.19–4.42
P = 0.01
Hyperglycaemia
aOR 2.27 (95% CI 1.19–4.42); P = 0.01
As reported in the abstract
- Worse 30-day mortality with MBG >180 mg/dL vs the other two groups
- P = 0.005
Observational data: associations, not effects.
Further findings
Early glycaemic control by device · first 72 h
- IABP had the best early glycaemic control; ECMO had the highest MBG
Original publication
Glycemic patterns and impact of early hyperglycaemia in patients with cardiogenic shock on mechanical circulatory support. Eur Heart J Acute Cardiovasc Care. Published 3 April 2023. doi:10.
Summarised from the published abstract; every number is checked against it