Heart failure & cardiomyopathies
Goal-Directed Versus Self-Directed Valsalva Maneuver in Patients With Hypertrophic Cardiomyopathy on Cardiac Myosin Inhibitor Therapy
Authors' conclusion
GDV can significantly alter patient management in patients with obstructive HCM on cardiac myosin inhibitor therapy by reclassifying disease severity, preventing unnecessary dose reductions in medications, and reducing the burden of frequent TTEs.
Study context
- Population
- Patients with obstructive hypertrophic cardiomyopathy (HCM) on mavacamten203 total transthoracic echocardiograms (TTEs)
- Participants
- 69 patients
- Exposure
- Goal-directed Valsalva (GDV) compared to self-directed Valsalva (SDV) in patients with obstructive HCM on mavacamten
- Outcome
- Mean pLVOTg
- Follow-up
- Initial postmavacamten TTEs
Main finding
As reported in the abstract
P < 0.01
Observational data: associations, not effects.
Further findings
Patients maintaining pLVOTg ≤20 mm Hg · fewer patients with GDV
P < 0.01
Patients maintaining Peak LVOT gradient (pLVOTg) ≤20 mm Hg
- Decreased medication reductions and reduced TTE follow-up in the GDV cohort
Original publication
Goal-Directed Versus Self-Directed Valsalva Maneuver in Patients With Hypertrophic Cardiomyopathy on Cardiac Myosin Inhibitor Therapy. JACC Adv. Published 8 January 2025. doi:10.
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