GOULD EDU: Cluster-Randomized Trial of an Educational Intervention to Improve Lipid-Lowering Guideline Adherence
Authors' conclusion
An educational intervention with physicians had little impact on LLT optimization or LDL-C goal achievement in patients with ASCVD over a 1-year period.
Study context
- Population
- US patients with atherosclerotic cardiovascular disease (ASCVD) in the GOULD registry
- Participants
- 616 vs 382
- Comparison
- Physician educational intervention in lipid-lowering therapy (LLT) optimisation
- Step 1n = 616
- Step 2n = 382
- Primary endpoint
- Optimisation of LLT (change in prescribed LLT)
- Follow-up
- 1 year
Methodological detailsextension of the GOULD observational registry, cluster-randomized, 1-year extension in a subset of registry sites
- Extension of the GOULD observational registry
- Cluster-randomized
- 1-year extension in a subset of registry sites
Primary result
As reported in the abstract
Change in prescribed LLT
No change in LLT
83.6%
820/981
LLT intensification
7.0%
69/981
Further findings
Low-density lipoprotein cholesterol (LDL-C) <70 mg/dL goal achievement
- Baseline
- 39.0% (202/518)
- 1 year
- 39.5% (252/638)
Original publication
GOULD EDU: Cluster-Randomized Trial of an Educational Intervention to Improve Lipid-Lowering Guideline Adherence. JACC Adv. Published 3 December 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →