Graft Failure After Coronary Artery Bypass Grafting and Its Association With Patient Characteristics and Clinical Events: A Pooled Individual Patient Data Analysis of Clinical Trials With Imaging Follow-Up
Pooled result · MI or repeat revascularization between CABG and imagingResult — go to the resultAdjusted odds ratio 3.98 95% CI 3.54–4.47Authors' conclusion
In contemporary practice, graft failure remains common among patients undergoing CABG and is strongly associated with adverse cardiac events.
Study context
- Population
- Patients undergoing coronary artery bypass grafting (CABG) in RCTs with systematic graft imaging
- Participants
- 4,413 patients · 7 trials
- Comparison
- Graft failure vs no graft failure
- Graft failuren = 1,487
- Outcome
- MI or repeat revascularization after CABG and before imaging
- Follow-up
- Median time to imaging 1.02 years (IQR 1.00-1.03)
Methodological details2-stage meta-analytic approach, systematic graft imaging follow-up
- 2-stage meta-analytic approach
- Systematic graft imaging follow-up
Pooled result
As reported in the abstract
MI or repeat revascularization between CABG and imaging
Adjusted odds ratio
3.98
95% CI 3.54–4.47
P < 0.001
By group
Graft failure vs No graft failure
aOR 3.98 (95% CI 3.54–4.47); P < 0.001
Further pooled results
| Outcome | Graft failure | No graft failure | aOR (95% CI) | P value | |
|---|---|---|---|---|---|
| Factors associated with graft failureAge (per 10-year increment) | 1.08 (1.01–1.15) | P = 0.03 | |||
| MI or repeat revascularization after imaging | 7.8% | 2.0% | 2.59 (1.86–3.62) | P < 0.001 | |
| All-cause death after imaging | 11.0% | 2.1% | 2.79 (2.01–3.89) | P < 0.001 | |
| 0.20.5125Adjusted odds ratio (log scale) |
Factors associated with graft failure
| Comparison | aOR (95% CI) | P value | |
|---|---|---|---|
| Female sex | 1.27 (1.08–1.50) | P = 0.004 | |
| Smoking | 1.20 (1.04–1.38) | P = 0.01 | |
| StatinsProtective | 0.74 (0.63–0.88) | P < 0.001 | |
| 0.512Adjusted odds ratio (log scale) |
Incidence of graft failure
- Patients with graft failure
- 1487 (33.7%)
- Grafts failed
- 2190 (16.6%)
Original publication
Graft Failure After Coronary Artery Bypass Grafting and Its Association With Patient Characteristics and Clinical Events: A Pooled Individual Patient Data Analysis of Clinical Trials With Imaging Follow-Up. Circulation. Published 7 July 2023. doi:10.
Summarised from the published abstract; every number is checked against it