Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data
Pooled result · MACCEResult — go to the resultAdjusted hazard ratio 1.12 95% CI 1.04–1.21Authors' conclusion
Women have worse outcomes than men in the first 5 years after CABG. This difference is not significant in patients aged over 75 years and is not affected by the surgical technique.
Study context
- Population
- Patients undergoing coronary artery bypass grafting (CABG) in large CABG trials
- Participants
- 13,193 patients · 4 trials
- Comparison
- Women vs men after CABG
- Womenn = 2,714
- Menn = 10,479reference
- Outcome
- MACCE:
- All-cause mortality
- Myocardial infarction (MI)
- Stroke
- Repeat revascularization
- Follow-up
- 5 years
Methodological detailsmultivariable mixed-effect Cox regression
- Multivariable mixed-effect Cox regression
Pooled result
MACCE
Adjusted hazard ratio
1.12
95% CI 1.04–1.21
P = 0.004
Women vs Men
adjusted HR 1.12 (95% CI 1.04–1.21); P = 0.004
As reported in the abstract
Further pooled results
| Outcome | Adjusted HR (95% CI) | P value | |
|---|---|---|---|
| All-cause mortality · 5 years | 1.03 (0.94–1.14) | P = 0.51 | |
| MI | 1.30 (1.11–1.52) | ||
| Repeat revascularization | 1.22 (1.04–1.43) | ||
| Stroke | 1.17 (0.90–1.52) | ||
| 0.512Adjusted hazard ratio (log scale) |
MACCE, patients ≥75 years (subgroup)
- Sex difference in MACCE not significant in patients 75 years and older
MACCE by off-pump surgery and multiple arterial grafting
- Off-pump surgery and multiple arterial grafting did not modify the sex difference
Original publication
Sex differences in outcomes after coronary artery bypass grafting: a pooled analysis of individual patient data. Eur Heart J. Published 2 August 2021. doi:10.
Summarised from the published abstract; every number is checked against it