Heart failure & cardiomyopathies
Guideline Implementation, Drug Sequencing, and Quality of Care in Heart Failure: Design and Rationale of TITRATE-HF
Study context
- Population
- Patients with HF with reduced ejection fraction (HFrEF), heart failure (HF) with mildly reduced EF and HF with improved EF (de novo, chronic and worsening HF)planned enrolment
- Participants
- 4,000 patients
- Primary endpoint
- HF-related hospitalizations, HF-related urgent visits needing intravenous diuretics, all-cause mortality and CV mortality
- Follow-up
- At least 3 years
Methodological detailsreal-world, longitudinal, >40 Dutch centres, Aims: sequencing strategies for guideline-directed medical therapy (GDMT) initiation, dose titration patterns (order and speed), GDMT intolerance, implementation barriers and long-term outcomes, Detailed titration steps collected for the four GDMT drug classes (date, primary reason for change, potential intolerances)
- Real-world
- Longitudinal
- >40 Dutch centres
- Aims: sequencing strategies for GDMT initiation, dose titration patterns (order and speed), GDMT intolerance, implementation barriers and long-term outcomes
- Detailed titration steps collected for the four GDMT drug classes (date, primary reason for change, potential intolerances)
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Guideline Implementation, Drug Sequencing, and Quality of Care in Heart Failure: Design and Rationale of TITRATE-HF. ESC Heart Fail. Published 8 December 2023. doi:10.
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