Heart failure & cardiomyopathies
Causal relationships between the gut microbiome, blood lipids, and heart failure: a Mendelian randomization analysis
Main finding · Gut microbial taxa and HFResult — go to the resultOdds ratio 1.059 95% CI 1.022–1.097Authors' conclusion
The study suggested a causal relationship between specific gut microbial taxa and HF and that ApoB might mediate this relationship as the primary lipid determinant of HF.
Study context
- Population
- GWAS summary statistics: gut microbial taxa (Dutch Microbiome Project, n = 7738), blood lipids (UK Biobank, n = 115,078), heart failure (HF) meta-analysis (115,150 cases, 1550 331 controls)
- Outcome
- Causal relationship between gut microbiome and HF (inverse-variance weighted method)
Methodological detailsbidirectional, mediation, multivariable Mendelian randomization (MR) (MR-BMA)
- Bidirectional
- Mediation
- Multivariable MR (MR-BMA)
Main finding
Gut microbial taxa and HF
Odds ratio
1.059
95% CI 1.022–1.097
P = 0.0017
Bacteroides dorei
OR 1.059 (95% CI 1.022–1.097); P = 0.0017
As reported in the abstract
- Microbial taxa suggestively associated with HF causally
- 6
Further findings
| Outcome | Proportion mediated (95% CI) | P value |
|---|---|---|
| Mediation of B. dorei effect on HF by ApoB | 10.1% (0.2–21.6%) | P = 0.031 |
Most likely causal lipid for HF (MR-BMA)
- Apolipoprotein B (ApoB) marginal inclusion probability
- 0.717
- P-value = 0.005
Original publication
Causal relationships between the gut microbiome, blood lipids, and heart failure: a Mendelian randomization analysis. Eur J Prev Cardiol. Published 17 May 2023. doi:10.
Summarised from the published abstract; every number is checked against it