Pulmonary vascular disease & thromboembolism
Haemodynamic Consequences of Acute Pulmonary Embolism Predict Risk of CTPA-Related Acute Kidney Injury
Authors' conclusion
AKI present in 11% of all PE patients diagnosed with CTPA is associated with embolism severity, measured by BOVA score, and RV dysfunction as defined by higher NT-proBNP, while not to pre-existing CKD or DM2.
Study context
- Population
- Patients with first episode of acute PE without haemodynamic instability undergoing computed tomography pulmonary angiography (CTPA)
- Participants
- 411 patients
- Exposure
- Acute kidney injury (AKI) (+) vs AKI (-)
- AKI (+)n = 46
- Outcome
- Frequency and predictors of AKI (creatinine increase ≥0.3 mg%) after CTPA
- Follow-up
- Within 72 h following CTPA
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
AKI after CTPA · within 72 h
Odds ratio (95% CI)P value
BOVA score
1.431(1.110–1.845)
P = 0.006NT-proBNP > 3314 pg/mL
3.765(1.572–9.016)
P = 0.003- AKI incidence
- 46 pts (11.2%)
Observational data: associations, not effects.
Further findings
AKI by BOVA and N terminal pro brain natriuretic peptide (NT-proBNP) combination
- BOVA ≥ 3 points and NT-proBNP ≥ 3314 pg/mL
- almost 32%
- BOVA < 3 points and NT-proBNP < 3314 pg/mL
- 5%
Characteristics of AKI (+) vs AKI (-)
- AKI (+) had higher sPESI, more pronounced right ventricular (RV) dysfunction, higher NT-proBNP, and more often pre-existing chronic kidney disease (CKD) and diabetes mellitus (DM2)
Original publication
Haemodynamic Consequences of Acute Pulmonary Embolism Predict Risk of CTPA-Related Acute Kidney Injury. ESC Heart Fail. Published 21 August 2025. doi:10.
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