Pulmonary vascular disease & thromboembolism
Noninvasive Estimation of Pulmonary Vascular Resistance Using Right Ventricular Outflow Doppler Analysis
Authors' conclusion
This novel echocardiographic method offers feasible, rapid, reliable PVR estimation with strong correlation to invasive measurements. Although not a substitute for RHC, this promising preliminary finding from a selective cohort may aid in identifying candidates for invasive testing and guide pulmonary hypertension management. Larger, multicenter validation is warranted.
Study context
- Population
- Patients undergoing right heart catheterization with interpretable right ventricular outflow tract Dopplersof 95 patients undergoing right heart catheterization (RHC), 35 with isolated postcapillary pulmonary hypertension (pulmonary vascular resistance (PVR) <2.0 WU) and no discernible Doppler notches excluded
- Participants
- 54 patients
- Exposure
- The model was validated against invasive PVR (iPVR) and compared with 5 existing methods.
- Derivationn = 30
- Validationn = 24
- Outcome
- Predictor of iPVR (stepwise linear regression)
Methodological detailsdevelopment and validation of a novel echocardiographic method
- Development and validation of a novel echocardiographic method
Main finding
As reported in the abstract
Model R2 after adjusting for heart rate
0.93
Equation
non-iPVR = 7.1∗(ejection time/NT) - 9.36
Observational data: associations, not effects.
Further findings
Validation against 5 established methods
- Superior performance across PVR range
- 2.3 to 14.2 WU
- Pearson correlation
- r: 0.76; P < 0.0001; 95% CI: 0.52-0.89
- Bland-Altman analysis confirmed superior agreement
Original publication
Noninvasive Estimation of Pulmonary Vascular Resistance Using Right Ventricular Outflow Doppler Analysis. JACC Adv. Published 18 August 2025. doi:10.
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