Heart failure & cardiomyopathies
Health-Related Quality of Life Among Transthyretin Amyloid Cardiomyopathy Patients
Authors' conclusion
KCCQ scores were lower than previously reported for patients with other heart diseases of non-ATTR CM origin. The HRQoL measures correlated well to NYHA class and NAC disease stage. The prevalence of depression appeared to be low.
Study context
- Population
- Adults (≥18 years) with symptomatic transthyretin amyloid cardiomyopathy (ATTR CM)
- Participants
- 169 adults
- Outcome
- HRQoL (KCCQ, EQ-5D-5L index and VAS, Major Depression Inventory)
Methodological detailsnon-interventional, multicentre (12 cardiology clinics in Norway, Sweden, Finland and Denmark)
- Non-interventional
- Multicentre (12 cardiology clinics in Norway, Sweden, Finland and Denmark)
Main finding
As reported in the abstract
HRQoL scores
- Kansas City Cardiomyopathy Questionnaire (KCCQ) total symptom score, mean ± SD
- 64.3 ± 23.1
- KCCQ overall summary score, mean ± SD
- 64.8 ± 20.9
- KCCQ clinical summary score, mean ± SD
- 65.1 ± 21.5
- EQ-5D-5L total utility score
- 0.8 ± 0.2
- EQ-5D-5L Visual Analog Scale (VAS) score
- 62.9 ± 20.6
- No signs of depression
- 89%
Observational data: associations, not effects.
Further findings
Health-related quality of life (HRQoL) by ATTR CM type
- Higher KCCQ overall summary score (OSS) in ATTRv CM vs ATTRwt CM; EQ-5D-5L utility, VAS and Major Depression Inventory (MDI) similar
HRQoL by randomized clinical trials (RCT) participation
- Poorer HRQoL in non-RCT vs RCT participants (lower KCCQ OSS and EQ-5D-5L VAS, higher MDI)
HRQoL by New York Heart Association (NYHA) class and National Amyloidosis Centre (NAC) stage
- Correlation of KCCQ, EQ-5D-5L and MDI with NYHA class significant after adjusting for multiple testing
- P < 0.05
- Poorer HRQoL with higher NYHA class and NAC stage (lower KCCQ and EQ-5D-5L, higher MDI)
Original publication
Health-Related Quality of Life Among Transthyretin Amyloid Cardiomyopathy Patients. ESC Heart Fail. Published 22 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →