Heart failure & cardiomyopathies
Timing of cardiac resynchronization therapy implantation
Authors' conclusion
In this study of a healthcare system covering an entire nation, delays from a first HFH to CRT implantation were associated with progressively worse long-term clinical outcomes.
Study context
- Population
- Patients undergoing cardiac resynchronization therapy (CRT) implantation in England, 2010–2019 (age 71.4 ± 11.7 years; 74.8% male)
- Participants
- 64,968 patients272,989 person-years
- Exposure
- Timing of CRT implantation relative to first heart failure hospitalization (HFH) vs CRT with no previous HFH
- Outcome
- Total mortality, HFH, and total mortality or HFH in relation to time from first HFH to CRT implantation
- Follow-up
- Median 4.54 (IQR 2.80-6.71) years
Methodological detailsnational population database (England)
- National population database (England)
Main finding
As reported in the abstract
Per year from first HFH to CRT vs no previous HFH (adjusted)
Time from first HFH to CRT (per year) vs No previous HFHHazard ratio (95% CI)
Total mortality
1.15(1.14–1.16)
HFH
1.26(1.24–1.28)
- Total mortality or HFH (CI as printed)
- HR 1.19 (95% CI 1.27–1.20)
Observational data: associations, not effects.
Further findings
| Outcome | HR | P value |
|---|---|---|
| CRT ≥2 years after first HFHCRT ≥2 years after first HFH vs No previous HFH · total mortality | 1.67 | P < 0.001 |
| CRT ≥2 years after first HFHCRT ≥2 years after first HFH vs No previous HFH · HFH | 2.63 | P < 0.001 |
| CRT ≥2 years after first HFHCRT ≥2 years after first HFH vs No previous HFH · total mortality or HFH | 1.92 | P < 0.001 |
CRT ≥2 years after first HFH
- Outcomes highest with CRT ≥2 years after first HFH
Original publication
Timing of cardiac resynchronization therapy implantation. Europace. Published 22 March 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →