Pulmonary vascular disease & thromboembolism
Healthy Plant-Based Diet, Genetic Predisposition, and the Risk of Incident Venous Thromboembolism
Main finding · VTEResult — go to the resultHazard ratio 0.86 95% CI 0.80–0.92Authors' conclusion
Adherence to a healthy plant-based dietary pattern could reduce the risk of developing VTE independent of genetic background, lifestyles, sociodemographic features, and multiple morbidities.
Study context
- Population
- White British UK Biobank participants free of venous thromboembolism (VTE) at baseline4,587 VTE cases
- Participants
- 183,510 participants
- Exposure
- Highest vs lowest tertile of hPDI; high vs low genetic risk
- Outcome
- Incident VTE (PE and DVT subtypes)
- Follow-up
- Mean 13 years
Methodological detailsUK Biobank
- UK Biobank
Main finding
VTE
Hazard ratio
0.86
95% CI 0.80–0.92
P = 0.02 for trend
Highest tertile of hPDIvs Lowest tertile of hPDI
HR 0.86 (95% CI 0.80–0.92); P for trend = 0.02
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| VTE, highvs low PRSAdjusted; 47% increase in VTE risk | 1.47 (1.37–1.58) | |
| VTE, joint hPDI and PRSLow hPDI and high PRSvs High hPDI and low PRSHighest risk | 1.72 (1.52–1.95) | |
| 0.512Hazard ratio (log scale) |
- VTE, joint hPDI and polygenic risk score (PRS) — No significant interaction between hPDI and PRS
- P interaction = 0.540
- VTE, joint hPDI and PRS: P interaction = 0.540
Original publication
Healthy Plant-Based Diet, Genetic Predisposition, and the Risk of Incident Venous Thromboembolism. JACC Adv. Published 16 October 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →