Pulmonary vascular disease & thromboembolism
Prognostic Value of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Predicting Venous Thromboembolism in Children With Lymphoma
Authors' conclusion
Fluorine-18-fluorodeoxyglucose PET/CT imaging detects treatment-induced venous toxicity that may provide insight into risk of VTE events in pediatric and adolescent and young adult patients with lymphoma.
Study context
- Population
- Pediatric, adolescent and young adult patients with lymphoma undergoing whole-body positron emission tomography (PET)/computed tomography (CT) at initial staging and first therapeutic follow-up
- Participants
- 71 participants
- Exposure
- 18F-FDG PET/CT venous inflammation in patients with vs without venous thromboembolism (VTE)
- Outcome
- Prognostic value of serial changes in lower extremity (femoral, popliteal) venous 18F-FDG uptake for predicting VTE
- Follow-up
- 12 months after lymphoma diagnosis
Main finding
As reported in the abstract
Venous inflammatory response on PET/CT · 12 months after diagnosis
ROC AUC for VTE occurrence, femoral vein
0.76
ROC AUC for VTE occurrence, popliteal vein
0.77
Observational data: associations, not effects.
Further findings
Association of PET/CT-derived vein inflammation changes with VTE-free survival (univariate) · 12 months after diagnosis
- Femoral vein inflammation significantly associated with VTE-free survival
- P = 0.008
- Popliteal vein inflammation significantly associated with VTE-free survival
- P = 0.002
- Univariate analyses
Original publication
Prognostic Value of Fluorine-18-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Imaging for Predicting Venous Thromboembolism in Children With Lymphoma. Circ Cardiovasc Imaging. Published 4 April 2023. doi:10.
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