Heart failure & cardiomyopathies
Heart Failure Following Anti-Inflammatory Medications in Patients With Type 2 Diabetes Mellitus
Main finding · HF hospitalizationResult — go to the resultOdds ratio 1.43 95% CI 1.27–1.63Authors' conclusion
NSAIDs were widely used and were associated with an increased risk of first-time HF hospitalization in patients with T2DM. Patients with advanced age, elevated HbA1c levels, and new users of NSAID seemed more susceptible.
Study context
- Population
- Patients diagnosed with T2DM in Denmark 1998–2021, without previous heart failure (HF), rheumatic disease or NSAID use 120 days before diagnosis23,308 hospitalized with HF
- Participants
- 331,189 patients
- Comparison
- Short-term NSAID use vs no use
- Outcome
- First-time HF hospitalization
Methodological detailsnationwide Danish registers, 28-day exposure windows
- Nationwide Danish registers
- 28-day exposure windows
Main finding
HF hospitalization
Odds ratio
1.43
95% CI 1.27–1.63
NSAID usevs No NSAID use
OR 1.43 (95% CI 1.27–1.63)
As reported in the abstract
Further findings
| Outcome | OR (95% CI) | |
|---|---|---|
| HF hospitalization by subgroupNSAID usevs No NSAID useAge ≥80 years | 1.78 (1.39–2.28) | |
| HF hospitalization by subgroupNSAID usevs No NSAID useElevated HbA1c treated with 0 to 1 antidiabetic drug | 1.68 (1.00–2.88) | |
| HF hospitalization by subgroupNSAID usevs No NSAID useWithout previous use of NSAIDs | 2.71 (1.78–4.23) | |
| 0.20.5125Odds ratio (log scale) |
NSAID use within 1 year
- Patients claiming ≥1 NSAID prescription
- 16%
Original publication
Heart Failure Following Anti-Inflammatory Medications in Patients With Type 2 Diabetes Mellitus. J Am Coll Cardiol. Published 18 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →