Heart failure with preserved ejection fraction in adults with congenital heart disease
Authors' conclusion
Heart failure with preserved ejection fraction is highly prevalent among ACHD patients, regardless of ACHD severity. It is associated with an increased burden of cardiovascular risk factors and hospitalizations. Despite this, only a minority received SGLT2 inhibitors.
Study context
- Population
- Adults with congenital heart disease (ACHD) patients with biventricular physiology and systemic LV, followed at ACHD centres in Eastern Denmark
- Participants
- 4,507 patients
- Exposure
- Heart failure with preserved ejection fraction (HFpEF) vs normal LV function
- Outcome
- Prevalence of HFpEF
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
HFpEF prevalence
- HFpEF prevalence, all ACHD
- 13%
- HFpEF prevalence, mild ACHD
- 13%
- HFpEF prevalence, moderate ACHD
- 12%
- HFpEF prevalence, severe ACHD
- 18%
- Preserved LVEF
- 86%
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Comorbidities (age-adjusted) — HFpEF vs Normal LV function · diabetes · age-adjusted | OR 15.60 (95% CI 12.39–19.70) | ||
| Comorbidities (age-adjusted) — HFpEF vs Normal LV function · obesity · age-adjusted | OR 1.48 (95% CI 1.17–1.87) | ||
| Comorbidities (age-adjusted) — HFpEF vs Normal LV function · AF · age-adjusted | OR 4.58 (95% CI 2.22–9.88) | ||
| CV hospitalization | IRR 4.6 (95% CI 4.2–5.1) | P < 0.0001 | |
| 0.050.21520Ratio (log scale) |
| Outcome | HFpEF | Normal left ventricular function | Estimate | P value | |
|---|---|---|---|---|---|
| Age | median 60 (IQR 47–70) years | Not reported in the abstract | P < 0.001 | Normal left ventricular function: not reported in the abstract |
- Age: Normal LV function median 41 (IQR 29–56) years
HF diagnosis and SGLT2 inhibitor use in HFpEF
- HF diagnosis recorded
- 4.0%
- Treated with SGLT2 inhibitor
- 5.8%
Original publication
Heart failure with preserved ejection fraction in adults with congenital heart disease. Eur Heart J. Published 30 January 2026. doi:10.
Summarised from the published abstract; every number is checked against it