Heart failure & cardiomyopathies
Heart Failure with Preserved Ejection Fraction in Haemodialysis Patients: Prevalence, Diagnosis, Risk Factors, Prognosis
Authors' conclusion
The majority of MHD patients with HF were categorized into HFpEF, with a poor long-term survival rate. NT-proBNP beyond 4922.5 pg/mL performed well in the prediction of HFpEF in MHD patients.
Study context
- Population
- Patients on maintenance haemodialysis for over 3 months, evaluated for heart failure (HF) by ESC guidelines
- Participants
- 439 patients
- Exposure
- Heart failure with preserved ejection fraction (HFpEF) vs no HF in maintenance haemodialysis (MHD) patients
- HFpEFn = 94
- Outcome
- Prevalence, diagnosis, risk factors and prognosis (all-cause mortality) of HFpEF
- Follow-up
- Median 22.5 months
Main finding
As reported in the abstract
MHD patients diagnosed with HF
111
25.3%
HF patients classified as HFpEF
94
84.7%
Observational data: associations, not effects.
Further findings
| Outcome | Values | HR (95% CI) | P value | |
|---|---|---|---|---|
| All-cause mortality · median follow-up 22.5 months | 2.47 (1.55–3.91) | P < 0.0001 | ||
| 0.20.5125Hazard ratio (log scale) |
| Outcome | Values |
|---|---|
| NT-proBNP for predicting HFpEF | NT-proBNP cut-off 4922.5 pg/mL · sensitivity 0.840 · specificity 0.723 · AUC 0.866 |
Risk factors for HFpEF
- Independent risk factors: age, DM, CAD, serum phosphorus
- Protective factors: normal urine volume, haemoglobin, serum iron, serum sodium
Original publication
Heart Failure with Preserved Ejection Fraction in Haemodialysis Patients: Prevalence, Diagnosis, Risk Factors, Prognosis. ESC Heart Fail. Published 2 July 2023. doi:10.
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