Heart failure & cardiomyopathies
Heart transplant outcomes in patients with substance use disorder history: a nationwide cohort study using high-dimensional propensity score matching
Main finding · MortalityResult — go to the resultOdds ratio 0.96 95% CI 0.54–1.69Authors' conclusion
Future studies must consider confounding factors when evaluating transplant criteria and outcomes in patients with SUDs.
Study context
- Population
- Heart transplantation patients with and without substance use disorders, USA (2015–23)
- Participants
- 808 vs 7,066
- Exposure
- Heart transplantation (HT) outcomes of patients with and without substance use disorders (SUDs)
- SUDsn = 808
- Controlsn = 7,066reference
- Outcome
- Mortality
- Follow-up
- 1 year
Methodological detailshigh dimensional propensity score matching, national dataset of electronic health records
- High dimensional propensity score matching
- National dataset of electronic health records
Main finding
As reported in the abstract
Odds ratio
0.96
95% CI 0.54–1.69
P = 0.88
SUDsvs controls
OR 0.96 (95% CI 0.54–1.69); P = 0.88
Observational data: associations, not effects.
Further findings
| Outcome | Estimate | P value | |
|---|---|---|---|
| Hospitalization · 1 year | OR 1.02 (95% CI 0.83–1.25) | P = 0.840 | |
| Organ rejection · 1 year | OR 0.96 (95% CI 0.78–1.18) | P = 0.670 | |
| Mortality · 5 years | HR 1.15 (95% CI 0.82–1.61) | P = 0.410 | |
| Organ rejection · 5 years | HR 0.98 (95% CI 0.84–1.14) | P = 0.810 | |
| 0.512Ratio (log scale) |
Original publication
Heart transplant outcomes in patients with substance use disorder history: a nationwide cohort study using high-dimensional propensity score matching. Eur Heart J Qual Care Clin Outcomes. Published 30 September 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →