Autonomic cardiac control independently predicts incident hypertension and systolic blood pressure in a multi-ethnic population: the HELIUS study

Bouwmeester, TA; Vriend, EMC; Galenkamp, H; Westerhof, BE; Collard, D; van den Born, BH

doi:10.1093/eurjpc/zwaf011

Hypertension

Autonomic cardiac control independently predicts incident hypertension and systolic blood pressure in a multi-ethnic population: the HEalthy Life In an Urban Setting (HELIUS) study

Eur J Prev CardiolPublished 16 Jan 2025Longitudinal cohort study

Main finding · Incident hypertensionResultOdds ratio 1.31 95% CI 1.09–1.57

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Authors' conclusion

In the general population, a lower xBRS is associated with increased odds of developing hypertension, and a steeper increase in SBP over time.

Study context

Population: Participants with and without a history of CVD from the HELIUS study; normotensives at baseline for incident hypertension

Exposure: Lower vs higher autonomic cardiac control at baseline
Outcome: New-onset hypertension in baseline normotensives
Follow-up: Median 6.6 years (IQR 5.8-7.4)

Methodological detailsmulti-ethnic, subgroup analyses by age (<50 and ≥50 years)

Multi-ethnic
Subgroup analyses by age (<50 and ≥50 years)

Main finding

Incident hypertension · median follow-up 6.6 years

Odds ratio

1.31

95% CI 1.09–1.57

Lowervs higher autonomic cardiac control (xBRS, SDNN, RMSSD) at baseline

OR 1.31 (95% CI 1.09–1.57)

As reported in the abstract

Observational data: associations, not effects.

Further findings

Outcome		Difference (mmHg) (95% CI)
Change in SBP between baseline and follow-up (full cohort)Highest tertilevs Lowest tertilexBRS; higher increase in SBP · linear regression	−20246	3.61 (2.50–4.71)
Change in SBP between baseline and follow-up (full cohort)Between Highest tertile and Lowest tertile · SDNN · linear regression	−20246	1.11 (0.12–2.09)
Change in SBP between baseline and follow-up (full cohort)Between Highest tertile and Lowest tertile · RMSSD · linear regression	−20246	1.76 (0.73–2.79)
	−20246Difference, mmHg (linear scale)

Original publication

Autonomic cardiac control independently predicts incident hypertension and systolic blood pressure in a multi-ethnic population: the HELIUS study. Eur J Prev Cardiol. Published 16 January 2025. doi:10.1093/eurjpc/zwaf011

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