Arrhythmias & electrophysiology
Hemolysis after pulsed-field ablation in pulmonary vein isolation for atrial fibrillation: A prospective controlled trial
Authors' conclusion
PFA using a multispline catheter with 8 and 16 applications per PV and focal PFA using CardioFocus (CardioFocus Inc., Massachusetts) platform showed no safety concerns with respect to hemolysis-induced AKI.
Study context
- Population
- Consecutive patients undergoing atrial fibrillation (AF) ablation, May 2022 to August 2024included in the final analysis
- Participants
- 200 patients
- Exposure
- Pulsed-field ablation (PFA) with different numbers and forms of applications vs radiofrequency ablation (RFA); post-ablation vs baseline hemolysis markers and indicators for acute kidney injury (AKI)
- Outcome
- Total bilirubin and lactate dehydrogenase
- Follow-up
- 24 hours after ablation
Methodological detailsconsecutive patients, prospectively enrolled
- Consecutive patients
- Prospectively enrolled
Main finding
As reported in the abstract
- Significant increase across all PFA modalities and RFA compared with baseline levels
Observational data: associations, not effects.
Further findings
Potassium levels · immediately post-ablation; 24 hours
- Increased significantly in all PFA modalities immediately post-ablation as compared with baseline, followed by a return to approximately baseline after 24 hours
- No significant potassium fluctuations were observed in RFA
Serum creatinine · within the 24-hour assessment period
- No significant increase in any PFA modality or RFA
Age of included patients
- Age
- 68.4 ± 10.8 years
Original publication
Hemolysis after pulsed-field ablation in pulmonary vein isolation for atrial fibrillation: A prospective controlled trial. Heart Rhythm. Published 23 April 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →