Arrhythmias & electrophysiology
High-frequency low-tidal volume ventilation improves procedural and long-term clinical outcomes in persistent atrial fibrillation ablation: Prospective multicenter registry
Corrected 23 Oct 2026: Measure wording clarified; no values changed.
Authors' conclusion
In patients undergoing RFCA with PVI + PWI for PeAF, the use of HFLTV ventilation was associated with higher freedom from all-atrial arrhythmias at 12-month follow-up, with significantly shorter procedural and RF times compared to SV, while reporting a similar safety profile.
Study context
- Population
- Patients with persistent AF undergoing radiofrequency catheter ablation (RFCA) with pulmonary vein isolation (PVI) + posterior wall isolation (PWI)REAL-AF registry
- Participants
- 210 patients
- Exposure
- High-frequency, low-tidal volume (HFLTV) ventilation vs standard ventilation during RFCA
- HFLTVn = 95
- Standard ventilation (SV)n = 115reference
- Outcome
- Freedom from all-atrial arrhythmias
- Follow-up
- 12 months
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
HR for all-atrial arrhythmia recurrence
0.41
95% CI 0.21–0.82
P = 0.012
By group
Observational data: associations, not effects.
Secondary outcomes
Procedural time
P < 0.001
Total RF time
P < 0.001
Pulmonary vein RF time
P < 0.001
Safety
Long-term procedure-related complications · no difference
P = 0.270
Original publication
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