Arrhythmias & electrophysiology
High initial heart rate score is an independent predictor of new atrial high-rate episodes in pacemaker patients with sinus node dysfunction
Main finding · New-onset AHREsResult — go to the resultHazard ratio 3.33 95% CI 1.35–8.18Authors' conclusion
HRSc ≥80% is associated with new-onset, device-determined AHREs for patients undergoing PM implantation for SND.
Study context
- Population
- Patients with sinus node dysfunction undergoing Boston Scientific pacemaker implantation 2012–2021, without prior AF or atrial high-rate episodes (AHREs) within 3 months after implantation
- Participants
- 130 consecutive pacemaker (PM) patients
- Exposure
- Initial Heart Rate Score (HRSc) ≥80% vs HRSc <80%
- Outcome
- New-onset AHREs (>1%, >6 h/d burden, atrial tachycardia response events >24 hours)
- Follow-up
- 48.9 (IQR 25.7-50.4) months
Methodological detailsconsecutive patients
- Consecutive patients
Main finding
New-onset AHREs
Hazard ratio
3.33
95% CI 1.35–8.18
P = 0.009
HRSc ≥80%vs HRSc <80%
HR 3.33 (95% CI 1.35–8.18); P = 0.009
As reported in the abstract
Observational data: associations, not effects.
Further findings
Male sex as predictor of AHREs
| HR (95% CI) | P value | ||
|---|---|---|---|
| Male sexAdjusted | 2.59 (1.06–6.33) | P = 0.04 | |
| 0.10.31310Hazard ratio (log scale) |
AHRE incidence by definition (all patients)
- AHRE >1% burden
- 27 of 130 (21%)
- AHRE >6 h/d burden
- 15 of 130 (12%)
- Atrial tachycardia response events >24 hours
- 9 of 130 (7%)
- Median initial HRSc
- 74% (57%-86%)
Original publication
High initial heart rate score is an independent predictor of new atrial high-rate episodes in pacemaker patients with sinus node dysfunction. Heart Rhythm. Published 25 June 2024. doi:10.
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