Randomised controlled trial
High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial
- Randomised controlled trial
- feasibility
Authors' conclusion
A high intensity exercise programme is feasible in patients with HCM, with apparent cardiovascular and psychological benefits, and no increase in arrhythmias.
Study context
- Population
- Patients with hypertrophic cardiomyopathy (HCM)67 (84%) completed
- Participants
- 40 vs 40
- Comparison
- Exercise vs Usual care
- Exercisen = 40
- Usual caren = 40reference
- Primary endpoint
- Feasibility (recruitment, adherence and retention rates; staffing ratios; logistics; acceptability); primary exploratory safety outcome: composite of arrhythmia-related events
- Follow-up
- 12 weeks
Primary result
As reported in the abstract
Feasibility
| Group | Value | Completed |
|---|---|---|
| Exercise | 34 events | 34 |
| Usual care | 33 events | 33 |
- Participants completed the study
- 67 (84%)
Secondary outcomes
| Outcome | difference (mmHg) (95% CI) | |
|---|---|---|
| SBP · 12 weeks | −7.3 (−11.7 to −2.8) | |
| −15−10−505Difference, mmHg (linear scale) |
| Outcome | difference (kg/m²) (95% CI) | |
|---|---|---|
| BMI · 12 weeks | −0.8 (−1.1 to −0.4) | |
| −1.5−1−0.500.5Difference, kg/m² (linear scale) |
| Outcome | difference (95% CI) | |
|---|---|---|
| Hospital anxiety score · 12 weeks | −3 (−4.3 to −1.7) | |
| Hospital depression score · 12 weeks | −1.7 (−2.9 to −0.5) | |
| −6−4−202Difference (linear scale) |
| Outcome | difference (mL/kg/min) (95% CI) |
|---|---|
| Peak VO2 · 12 weeks | +4.1 (1.1–7.1) |
| VO2 at anaerobic threshold · 12 weeks | +2.3 (0.4–4.1) |
Exercise gains · 6 months post-programme
- Most exercise gains dissipated at 6 months
Safety
| Outcome | P value |
|---|---|
| Composite of arrhythmia-related events (primary exploratory safety outcome) · no difference between groups | P = 0.99 |
Original publication
High intensity exercise programme in patients with hypertrophic cardiomyopathy: a randomized trial. Eur Heart J. Published 3 March 2025. doi:10.1093/eurheartj/ehae919
Summarised from the published abstract; every number is checked against it