Heart failure & cardiomyopathies
Cardiac Myosin Binding Protein C Correlate with Cardiac Troponin I During an Exercise Training Program in Patients with HFrEF
Authors' conclusion
Changes in levels of the novel biomarker cMyC were significantly associated with hs-cTnI serum levels in patients with symptomatic chronic HFrEF during a structured 12-week exercise training programme. This may indicate that cMyC has a role as a future marker of subclinical myocardial damage.
Study context
- Population
- Symptomatic heart failure patients (chronic HFrEF) undergoing a 12-week exercise training programmeserum available for cMyC testing, 196 for hs-cTni testing · cMyC testing 205 · hs-cTni testing 196
- Participants
- 205 patients
- Comparison
- Agreement and correlation of change in cMyC with change in hs-cTnI; change in cMyC in intervention group (IG) vs control group (CG)
Primary result
As reported in the abstract
Change in cMyC levels · 12 weeks
IG
−0.5
∆ cMyC · IQR −3.4–2.1
CG
−0.7
∆ cMyC · IQR −2.7–2.6
Further findings
Correlation of change in log hs-cTnI with change in log cMyC · 12-week intervention period
- Pearson correlation coefficient R
- 0.52 (95% CI 0.37-0.66, P < 0.001)
- For every 10% increase in cMyC levels, hs-cTnI levels rose by approximately
- 5%
Original publication
Cardiac Myosin Binding Protein C Correlate with Cardiac Troponin I During an Exercise Training Program in Patients with HFrEF. ESC Heart Fail. Published 23 January 2025. doi:10.
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