High-intensity interval training combined with moderate-intensity continuous training in post-PCI acute myocardial infarction patients: A randomized controlled trial
Authors' conclusion
Combined HIIT and MICT training produces synergistic effects, superior to single modalities, in improving cardiopulmonary function and cardiac remodeling in post-PCI AMI patients, with comparable safety profile, providing evidence-based optimization strategy for cardiac rehabilitation.
Study context
- Population
- Clinically stable post-PCI acute myocardial infarction (AMI) patientsenrolled and randomized
- Participants
- 204 patients
- Comparison
- Combined high-intensity interval training (HIIT) and moderate-intensity continuous training (MICT) training compared to single training modalities
- HIIT+MICTn = 68
- MICTn = 68
- HIITn = 68
- Primary endpoint
- Change in VO2peak
Methodological details12-week supervised cardiac rehabilitation
- 12-week supervised cardiac rehabilitation
Primary result
As reported in the abstract
HIIT+MICT
5.6
± 2.3 · mL/kg/min
MICT
2.7
± 1.9 · mL/kg/min
HIIT
4.2
± 1.8 · mL/kg/min
HIIT+MICT vs MICT: P < 0.001 · HIIT+MICT vs HIIT: P = 0.003
- HIIT+MICT reaching clinically meaningful improvement (≥3 mL/kg/min)
- 76.7%
Secondary outcomes
Left ventricular ejection fraction (LVEF) and NT-proBNP in the combined training group
- LVEF increased
- 8.6 ± 3.2%
- NT-proBNP decreased
- −706 pg/mL
Safety
- Incidence of major adverse cardiovascular events (MACE)
- 2.9%
- Without significant inter-group differences
- P = 0.85
Original publication
High-intensity interval training combined with moderate-intensity continuous training in post-PCI acute myocardial infarction patients: A randomized controlled trial. Am Heart J. Published 8 May 2026. doi:10.
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