Heart failure & cardiomyopathies
High Variability in Assays of Blood Markers of Collagen Turnover in Cardiovascular Disease: Implications for Research and Clinical Practice
Authors' conclusion
Our findings show that it is challenging to ascertain normal ranges or compare studies for the measurement of fibrosis biomarkers.
Study context
- Population
- Human in-vivo studies of blood markers of collagen turnover (fibrosis) in CVD89 studies
- Participants
- 42 / 32 / 29 / 17
- Comparison
- PIIINP vs PICP vs CITP vs PINP
- PIIINPn = 42
- PICPn = 32
- CITPn = 29
- PINPn = 17
- Outcome
- Range of reported values
Methodological detailsPRISMA
- PRISMA
Pooled result
As reported in the abstract
- Extreme variations in values across studies, especially with different assays, but also with the same assays
Original publication
High Variability in Assays of Blood Markers of Collagen Turnover in Cardiovascular Disease: Implications for Research and Clinical Practice. Eur J Heart Fail. Published 9 July 2024. doi:10.
Summarised from the published abstract; every number is checked against it