Acute cardiac care & resuscitation
Higher ventilation rate is associated with increased return of spontaneous circulation in in-hospital cardiac arrest patients with advanced airways
Primary result · ROSCResult — go to the resultAdjusted odds ratio 1.15 95 % CI 1.04–1.28Authors' conclusion
Ventilation rates above guideline recommendations were common. Rates between 12 and 26 breaths/min were associated with improved ROSC, potentially due to enhanced perfusion.
Study context
- Population
- Patients undergoing CPR for in-hospital cardiac arrest with an advanced airway and continuous ventilation and end-tidal CO2 (ETCO2) monitoringblood gas data for 127
- Participants
- 222 patients
- Comparison
- Ventilation rate >12 vs 6-12 breaths/min during CPR
- Primary endpoint
- Return of spontaneous circulation (ROSC)
Methodological detailsmulticentre, 25 tertiary centres in US and UK
- Multicentre
- 25 tertiary centres in US and UK
Primary result
ROSC
Adjusted odds ratio
1.15
95 % CI 1.04–1.28
P = 0.006
By group
Ventilation rate
adjusted OR 1.15 (95 % CI 1.04–1.28); P = 0.006
Per 2 breaths/min increase, as printed
As reported in the abstract
Further findings
ETCO2
P < 0.001
Ventilated >10 breaths/min
- Proportion of patients ventilated >10 breaths/min
- 84.7 %
PaO2 and PaCO2
- PaO2 and PaCO2 did not differ significantly
Original publication
Higher ventilation rate is associated with increased return of spontaneous circulation in in-hospital cardiac arrest patients with advanced airways. Resuscitation. Published 7 November 2025. doi:10.
Summarised from the published abstract; every number is checked against it