Valvular & structural heart disease
Histopathological maladaptive changes in the explanted human mitral leaflets correlate with changes in echocardiographic leaflet morphology and the severity of ischaemic mitral regurgitation
Authors' conclusion
In ischaemic MR, the thicker the cusps, the worse the MR. Leaflet thickening was due to the myxoid and fibrosis deposition and was detected by echocardiography.
Study context
- Population
- Patients with ischaemic mitral regurgitation; histology from explanted leaflets of those undergoing mitral valve replacement (MVR)48 with MVR (histology)
- Participants
- 250 patients
- Exposure
- Echocardiographic and histopathological mitral leaflet thickening vs ischaemic mitral regurgitation (IMR) severity
- Outcome
- Correlation of echocardiographic mitral valve (MV) thickening with IMR severity and histopathological basis of thickening
Main finding
As reported in the abstract
- Echo: anterior and posterior leaflet thickness greater in moderate to severe IMR
- P < 0.001
- Histology: base and cusp thickness greater in Group 2
- P < 0.05
- Thicker leaflets associated with greater degree of mitral regurgitation (MR)
- P < 0.0001
- Echo: median anterior leaflet thickness 3.5 mm independently associated with moderate to severe IMR, OR 2.88
- P < 0.01
- Echo: median posterior leaflet thickness 3.5 mm independently associated with moderate to severe IMR, OR 10.8
- P < 0.001
Observational data: associations, not effects.
Original publication
Histopathological maladaptive changes in the explanted human mitral leaflets correlate with changes in echocardiographic leaflet morphology and the severity of ischaemic mitral regurgitation. Eur Heart J Cardiovasc Imaging. Published 24 March 2022. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →