Valvular & structural heart disease
Hydrodynamic Assessment of Explanted Degenerated Transcatheter Aortic Valves: Novel Insights Into Noncalcific and Calcific Mechanisms
Authors' conclusion
TAV function can be severely impacted by noncalcific and calcific mechanisms of tissue degeneration. Importantly, functional stenosis can occur in TAVs in the absence of obvious and significant calcification.
Study context
- Population
- Explanted degenerated transcatheter aortic valves (EXPLANT THV registry and clinical institutions)
- Participants
- 14 explants
- Comparison
- Calcified vs noncalcified explanted transcatheter aortic valve (TAVs)
- Calcifiedn = 6
- Noncalcifiedn = 8reference
- Outcome
- Hydrodynamic mean gradient
Methodological detailsbench testing, explant analysis, 10 CoreValve/Evolut, 3 SAPIEN 3, 1 Lotus TAV, Median age at explantation 73.0 years (Q1-Q3: 64.5-80.0 years); time to explantation 4 years 1 month
- Bench testing
- Explant analysis
- 10 CoreValve/Evolut, 3 SAPIEN 3, 1 Lotus TAV
- Median age at explantation 73.0 years (Q1-Q3: 64.5-80.0 years); time to explantation 4 years 1 month
Main finding
As reported in the abstract
P = 0.28
- Leaflet calcification vs hydrodynamic mean gradient: weak, nonsignificant association
- r = 0.42; P = 0.14
Further findings
- Leaflet calcification volume (calcified explants)
- 162.4 · range 58.8–603.0 · mm³
Original publication
Hydrodynamic Assessment of Explanted Degenerated Transcatheter Aortic Valves: Novel Insights Into Noncalcific and Calcific Mechanisms. JACC Cardiovasc Interv. Published 10 June 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →