Arrhythmias & electrophysiology
HIV Infection Is Associated With Variability in Ventricular Repolarization: The Multicenter AIDS Cohort Study (MACS)
Main finding · QTVIResult — go to the resultAdjusted difference +0.077 95% CI +0.032 to +0.123Authors' conclusion
HIV+ men have greater beat-to-beat variability in QT interval (QTVI) than HIV- men, especially in the setting of HIV viremia and heightened inflammation.
Study context
- Population
- Men from MACS (Multicenter AIDS Cohort Study) with ambulatory ECG patch monitoringmen, MACS
- Participants
- 1,123 men
- Exposure
- HIV+ vs HIV- men
- HIV+n = 589
- HIV-n = 534reference
- Outcome
- QT variability index (QTVI; log measure of QT-interval variance indexed to heart rate variance)
Methodological detailsmulticentre cohort (MACS), ambulatory ECG patch, linear mixed-effects models, adjusted, Beat-to-beat analysis of up to 4 days of ECG data per participant; median analysed duration 78.3 [66.3-83.0] hours/person
- Multicentre cohort (MACS)
- Ambulatory ECG patch
- Linear mixed-effects models, adjusted
- Beat-to-beat analysis of up to 4 days of ECG data per participant; median analysed duration 78.3 [66.3-83.0] hours/person
Main finding
QTVI
Adjusted difference
+0.077
95% CI +0.032 to +0.123
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | Adjusted difference (95% CI) |
|---|---|
| QTVI by HIV viral load (subgroup)HIV+ undetectable VL vs HIV- | +0.064 (+0.017 to +0.111) |
| QTVI by HIV viral load (subgroup)HIV+ detectable VL vs HIV- | +0.150 (0.072–0.228) |
QT variability index (QTVI) subcomponents
- HIV+ men had lower heart rate variability irrespective of viral load (VL) status
- HIV+ men had higher QT variability with detectable, but not undetectable, VL
Inflammatory biomarkers
- Higher CRP, IL-6, ICAM-1, sTNFR2 and sCD163 (borderline) associated with higher QTVI and partially attenuated the association with HIV serostatus
Original publication
HIV Infection Is Associated With Variability in Ventricular Repolarization: The Multicenter AIDS Cohort Study (MACS). Circulation. Published 11 November 2019. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →