Arrhythmias & electrophysiology
Association Between Left Ventricular Scar and Ventricular Ectopy in People Living With and Without HIV
Main finding · High VE burden, ischemic or major nonischemic pattern LGEResult — go to the resultAdjusted odds ratio 2.32Authors' conclusion
Ischemic or major nonischemic pattern LGE and greater scar mass correlated with higher VE burden, independently of LV structure/function, HIV serostatus, and HIV viremia.
Study context
- Population
- People living with HIV (PLWH) and people without HIV (PWOH) with risk factors for HIV from 3 cohorts, undergoing ambulatory ECG monitoring (median wear time 8.3 days) and CMR109 with LGE
- Participants
- 329 participants
- Exposure
- Ischemic or major nonischemic pattern LGE vs none, with HIV as effect modifier
- Outcome
- Association of myocardial scar (late gadolinium-enhancement cardiovascular magnetic resonance (LGE-CMR)) with VE burden
Methodological details3 cohorts, multivariable regression
- 3 cohorts
- Multivariable regression
Main finding
As reported in the abstract
High VE burden, ischemic or major nonischemic pattern LGE
Adjusted odds ratio
2.32
P = 0.004
- More PVCs/day with ischemic or major nonischemic pattern LGE (141% higher)
- P < 0.001
Observational data: associations, not effects.
Further findings
PVCs/day by scar mass, among people with LGE
- Greater scar mass correlated with more PVCs/day
- P = 0.028
Original publication
Association Between Left Ventricular Scar and Ventricular Ectopy in People Living With and Without HIV. JACC Adv. Published 17 November 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →