Valvular & structural heart disease
Human Epididymis Protein 4 is a Useful Predictor of Post-Operative Prognosis in Patients with Severe Aortic Stenosis
Main finding · CV death or hospitalization for HFResult — go to the resultHazard ratio 7.50 95% CI 1.81–31.1Authors' conclusion
We found that HE4 is a potentially useful biomarker for predicting future CV events in patients scheduled for AS surgery.
Study context
- Population
- Patients with severe aortic stenosis (AS) before SAVR or TAVI, Kumamoto University Hospital, 2018
- Participants
- 55 patients
- Exposure
- High HE4 vs low HE4
- Outcome
- CV death or hospitalization for HF
- Follow-up
- 3 years
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Hazard ratio
7.50
95% CI 1.81–31.1
P = 0.005
Log(HE4)
HR 7.50 (95% CI 1.81–31.1); P = 0.005
Observational data: associations, not effects.
Further findings
Correlation of serum HE4 with CT-ECV
- Positive correlation, r
- 0.53
- P
- P = 0.004
ROC analysis of HE4 for cardiovascular (CV) death or heart failure (HF) hospitalization at 3 years · 3 years after surgery
- AUC
- 0.76 (95% CI 0.62-0.90; P = 0.003)
Original publication
Human Epididymis Protein 4 is a Useful Predictor of Post-Operative Prognosis in Patients with Severe Aortic Stenosis. ESC Heart Fail. Published 27 May 2024. doi:10.
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