Arrhythmias & electrophysiology
Human induced pluripotent stem cell–derived atrial cardiomyocytes recapitulate contribution of the slowly activating delayed rectifier currents I Ks to repolarization in the human atrium
Authors' conclusion
I Ks exists in hiPSC-aCM with biophysics not different from aCM. As in adult human atrium (SR and AF), IKs does not appear to relevantly contribute to repolarization in hiPSC-aCM.
Study context
- Population
- Human atrial tissue from patients with sinus rhythm (SR) or atrial fibrillation (AF), and hiPSC-aCM
- Comparison
- hiPSC-aCM vs human atrial cardiomyocytes
- Outcome
- Contribution of IKs to repolarization (IKs identified by HMR-1556 1 µM)
Methodological detailsAction potential recorded by sharp microelectrodes
- Action potential recorded by sharp microelectrodes
Main finding
As reported in the abstract
Less than 50% of hiPSC-aCM and atrial cardiomyocytes (aCM) possessed IKs
<50%
Original publication
Human induced pluripotent stem cell–derived atrial cardiomyocytes recapitulate contribution of the slowly activating delayed rectifier currents I Ks to repolarization in the human atrium. Europace. Published 24 May 2024. doi:10.
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