Arrhythmias & electrophysiology
Percutaneous left atrial appendage closure for stroke prevention in hypertrophic cardiomyopathy patients with atrial fibrillation
Main finding · Ischemic strokeResult — go to the resultHazard ratio 1.9Authors' conclusion
These real-world data do not support percutaneous LAAC in HCM-AF patients as the primary treatment strategy during long-term AC to reduce stroke risk.
Study context
- Population
- Patients with hypertrophic cardiomyopathy and atrial fibrillation (AF), TriNetX Global Research Network, 2015–2024matched cohort
- Participants
- 14,867 patients
- Exposure
- Percutaneous left atrial appendage closure (LAAC) vs anticoagulation (AC) alone
- LAACn = 364
- ACn = 14,503reference
- Outcome
- Ischemic stroke
- Follow-up
- 3 years
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
Hazard ratio
1.9
P = 0.006
By group
Observational data: associations, not effects.
Further findings
Systemic embolism · matched cohort
HR 1.8 · P = 0.006
All-cause mortality
- No difference in mortality
- Matched cohort
Original publication
Percutaneous left atrial appendage closure for stroke prevention in hypertrophic cardiomyopathy patients with atrial fibrillation. Heart Rhythm. Published 24 May 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →