Coronary disease & ACSCohort study
Human papillomavirus infection and cardiovascular mortality: a cohort study
- Prospective cohort study
Authors' conclusion
In this cohort study of young and middle-aged Korean women, at low risks for CVD mortality, those with HR-HPV infection had higher death rates from CVD, specifically ASCVD and IHD, with a more pronounced trend in obese individuals.
Study context
- Population
- Cardiovascular disease (CVD)-free Korean women undergoing high-risk human papillomavirus (HR-HPV) screening at a health examination (mean age 40.2 years)134 CVD deaths
- Participants
- 163,250 women
- Exposure
- HR-HPV(+) vs HR-HPV(-)
- Outcome
- CVD mortality (ASCVD, ischaemic heart disease (IHD), stroke) from national death records
- Follow-up
- Up to 17 years (median 8.6 years)
Main finding
As reported in the abstract
CVD mortality
HR-HPV(+)
14.9 per 105 person-years
HR-HPV(-)
9.1 per 105 person-years
HR-HPV(+) vs HR-HPV(-)Hazard ratio (95% CI)
ASCVD mortality, adjusted
3.91(1.85–8.26)
IHD mortality, adjusted
3.74(1.53–9.14)
stroke mortality, adjusted
5.86(0.86–40.11)
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | |
|---|---|---|
| ASCVD mortality, by obesity (subgroup) — HR-HPV(+) vs HR-HPV(-) · obese | 4.81 (1.55–14.93) | |
| ASCVD mortality, by obesity (subgroup) — HR-HPV(+) vs HR-HPV(-) · non-obese | 2.86 (1.04–7.88) | |
| 0.050.21520Hazard ratio (log scale) |
- Atherosclerotic CVD (ASCVD) mortality, by obesity (subgroup): P for interaction = .006
Original publication
Human papillomavirus infection and cardiovascular mortality: a cohort study. Eur Heart J. Published 7 February 2024. doi:10.1093/eurheartj/ehae020
Summarised from the published abstract; every number is checked against it