Arrhythmias & electrophysiology
Human use conditions in fatigue of intravenous leads used in cardiac implanted electronic devices
Authors' conclusion
HUCS is the first study to measure alternating in vivo stresses applied to leads from multiple manufacturers that spanned a range of stiffnesses and thereby enable the development of an evidence-based lead-testing standard. The greatest alternating stress occurs in the extravenous region. There, lead stiffness predicts how much of the lead is highly stressed but does not predict maximum alternating curvature.
Study context
- Population
- Subjects with transvenous leads from 4 manufacturers spanning the range of stiffness in clinical use, imaged by biplane cinefluoroscopy during cardiac motion and in the shoulder region during arm motionsubjects whose images were analyzed
- Participants
- 109 subjects
- Exposure
- Alternating curvature across lead regions and in relation to lead stiffness
- Outcome
- Maximum alternating curvature, determinants within each lead region
Main finding
As reported in the abstract
- Determined primarily by between-patient differences, not differences in lead stiffness
Observational data: associations, not effects.
Further findings
Maximum alternating curvature across regions
- Greatest in the extravenous region
- P = 0.001
Length of the highly stressed portion of the lead in the extravenous region
- Correlated inversely with lead stiffness
- P < 0.001
Original publication
Human use conditions in fatigue of intravenous leads used in cardiac implanted electronic devices. Heart Rhythm. Published 3 July 2025. doi:10.
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